Gene research has become increasingly more important due to the fact that researchers have discovered that so many different medical conditions can result as result of damage or mutation of the genes. For Xlhed, otherwise known as X-Linked Hypohidrotic Ectodermal Dysplasia, the history stems back to discovering that this condition is as a result of a mutation to the EDA gene. The “X” comes from the fact that the gene that is associated with this disorder is found on the X chromosome. Males only have one “X” chromosome and females have two X chromosomes. Xlhed can be present in either male or female. However, for the females both X chromosomes must be affected in order for this condition to be present. What is interesting to note is that when an X linked disorder is present it cannot be passed onto their sons.
The abnormality in the EDA gene that is going to lead to a child being born with Xlhed takes place in the embryo stage.
Understanding Xlhed can be confusing because there are different forms of Hed which include ARHED and ADHED.
Parents who are aware that Xlhed is present in their genes are often concerned as to whether they can pass this condition along to their children. As mentioned, a Father cannot pass it along to their son, but they can pass it on to their daughters. Mothers can pass it on to both sexes.
The diagnosis of Xlhed will usually come as a result of the health care provider noting that the child’s teeth may not be developing properly. Or they may notice abnormal hair growth or the parents may notice that their youngster does not seem to sweat. For positive confirmation, genetic testing can be done through a blood test to diagnose some forms of this disease.
Research is ongoing to help find a cure and a prevention for Xlhed but it is currently suspected that the best course of prevention will be through treating the embryo during the pregnancy.